Thiazole Synthesis by Thionation of C=O to C=S

The heterocyclic compounds play an important role in the construction and exploration of novel physiological/biologically active compounds. The five-membered aromatic compounds have been studied due their important physiological activities. The transformation of a carbonyl functional group into thiocarbonyl has a significant interest to synthetic organic researchers. Two reagents, Lawesson’s reagent and P4S10, are the most broadly utilized reagents for these types of conversions as well as for the formation of a wide range of heterocycles containing sulfur atom. Lawesson’s reagent has been the most broadly utilized reagent since the starting of the last quarter of the twentieth century.