Herb-Drug Interactions: Methods to Identify Potential Influence of Genetic Variations in Genes Encoding Drug Metabolizing Enzymes and Drug Transporters
2012
Herbal supplements are often used concomitantly with conventional medications resulting in considerable potential
for herb-drug interactions. These interactions, which are generally through interfering with pharmacokinetic and/or
pharmacodynamic pathways, may result in beneficial effects or more often adverse reactions such as toxicity or treatment
failure and may be influenced by multiple environmental and/or genetic factors. The pharmacogenetic approach may help
to identify some interactions which may be more pronounced or only occur in specific groups of subjects although the
complex nature of the herbal medicines may limit the discovery of such an interaction. Preclinical studies such as gene
expression profiling in rodent liver may help to define metabolic pathways influenced by herbal medicines and facilitate
more accurate targeting of human in vivo studies. This review discusses the mechanisms of herb-drugs interaction and the
potential influence of genetic variation on herb-drug interactions based on available clinical evidence.
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