The mitochondrial TOM complex modulates bax-induced apoptosis in Drosophila.

Abstract Bax is a pro-apoptotic member of the Bcl-2 family proteins involved in the release of apoptogenic factors from mitochondria to the cytosol. Recently, it has been shown both in mammals and yeast that Bax insertion in the mitochondrial outer membrane involves at least two distinct mechanisms, one of which uses the TOM complex. Here, we show that in Drosophila , heterozygous loss of function mutations of Tom22 or Tom70, two receptors of the TOM complex, attenuates bax -induced phenotypes in vivo . These results argue that the TOM complex may be used as a mitochondrial Bax receptor in Drosophila .