Targeted cortical reorganization using optogenetics in non-human primates

From riding a bike to reaching for a cup of coffee, all skilled actions rely on precise connections between the sensory and motor areas of the brain. While sensory areas receive and analyse input from the senses, motor areas plan and trigger muscle contractions. Precisely adjusting the connections between these and other areas enables us to learn new skills, and it also helps us to relearn skills lost as a result of brain injury or stroke. About 70 years ago, a psychologist named Donald Hebb came up with an idea for how this process might occur. He proposed that whenever two neurons are active at the same time, the connection between them becomes stronger. This idea, that ‘cells that fire together, wire together’, became known as Hebb’s rule. Many studies have since shown that Hebb’s rule can explain changes in the strength of connections between pairs of neurons. But can it also explain how connections between entire brain regions become stronger or weaker? New results show that it can. The data were obtained using a technique called optogenetics, in which viruses are used to introduce genes for light-sensitive proteins into neurons. Shining light onto the brain will then activate any cells within that area that contain the resulting proteins. Yazdan-Shahmorad, Silversmith et al. used this technique to activate small regions of either sensory or motor brain tissue in live macaque monkeys. Doing so strengthened the overall connectivity between the two areas. The effects were more variable at the level of smaller brain regions, with some connections becoming weaker rather than stronger. However, Yazdan-Shahmorad, Silversmith et al. show that Hebb’s rule explains most of the observed changes. Many neurological and psychiatric disorders stem from abnormal brain connectivity. Simple forms of brain stimulation are already used to treat certain neurological disorders, such as Parkinson’s disease. Stimulating the brain to induce specific changes in connectivity may ultimately enable us to leverage the brain’s natural learning mechanisms to cure, instead of just treat, these conditions.