Synthesis and Pharmacological Evaluation of Some DL-Dichlorophenyl Alcohol Amides Anticonvulsants

The anticonvulsant activity of a homologous series of DL-dichlorophenyl alcohol amides is described. The compounds DL-2-hydroxy-2- (3’,4’-dichlorophenyl) butyramide (4, CAS 620950-11-0), DL-3-hydroxy-3- (3’,4’-dichlorophenyl) pentanamide (5, CAS 620950-15-4) and DL-4-hydroxy-4- (3’,4’-dichlorophenyl) hexanamide (6, CAS 620950-17-6) were prepared and tested. Compounds 4, 5 and 6 exhibited a significant activity in seizures induced by pentetrazol. Incorporation of chlorine in the phenyl ring increased their potency. Compound 4 exhibited a slightly lower activity than the reference drug phenobarbital (CAS 50-06-6).