Synthesis and characterization of water-soluble titanocene complexes

Titanocene dichloride was a kind of metallorganic compound which has antitumor activity.Two complexes were synthesized via the reaction of titanocene dichloride with salicylic acid or methionine.These complexes were characterized by elemental analysis,IR spectroscopy,1HNMR and UVvis spectrometry.The experimental results showed that salicylate complex was an unimolecular bidentate titanocene complex,but methionine complex was an bimolecular unidentate titanocene complex.Methionine complex possessed good application outlook on the clinical trials because of its good water-soluble and fat-soluble properties.