Diverted Total Synthesis of Falcitidin Acyl Tetrapeptides as New Antimalarial Leads.

Santosh R. Kotturi,Brinda Somanadhan,Jun-Hong Ch’ng,Kevin S. W. Tan,Mark S. Butler,Martin J. Lear

Diverted Total Synthesis of Falcitidin Acyl Tetrapeptides as New Antimalarial Leads.

2014

Santosh R. Kotturi
Brinda Somanadhan
Jun-Hong Ch’ng
Kevin S. W. Tan
Mark S. Butler
Martin J. Lear

The total syntheses of antimalarial agent Falcitidin (I) as well as related N-acyl analogues (II) are outlined and the efficiency of the latter compounds against chloroquine-sensitive Plasmodium falciparum 3D7 is tested.

Keywords:

Plasmodium falciparum
Total synthesis
Antimalarial Agent
Chemistry
Organic chemistry

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations