Assessment of significance and forensic relevance of SE33 (ACTBP2) locus in five Indian populations

Abstract The study was conducted to evaluate the genetic variability, forensic reliability and potential of SE33 STR marker in five different Indian populations. 1400 blood samples of randomly selected unrelated individuals from various regions of Odisha (508), Madhya Pradesh (370), Telangana (305), Himachal Pradesh (168) and Rajasthan (49) were genotyped and evaluated for allelic diversity and statistical parameters for SE33 marker in selected Indian populations along with its comparison from global populations. This evaluation uncovered the highest discrimination power in population of Portugal (0.995), India (0.994), Bahrain (0.994) and Colombia (0.994). However, the highest observed heterozygosity was reported in Malaysian population (0.953) out of other reported populations. In all the studied five Indian populations SE33 was found to be have the highest discrimination power and lowest probability of match which envisions its application in varied applications of forensic DNA analysis such as human identification, paternity disputes and mass disaster as well as other population genetic studies.