The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

Simon Mysling,Kristian Kølby Kristensen,Mikael Larsson,Oleg Kovrov,André Bensadouen,Thomas J. D. Jørgensen,Gunilla Olivecrona,Stephen G. Young,Michael Ploug

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

2016

Simon Mysling
Kristian Kølby Kristensen
Mikael Larsson
Oleg Kovrov
André Bensadouen
Thomas J. D. Jørgensen
Gunilla Olivecrona
Stephen G. Young
Michael Ploug

Lipoprotein lipase (LPL) undergoes spontaneous inactivation via global unfolding and this unfolding is prevented by GPIHBP1 (Mysling et al., 2016). We now show: (1) that ANGPTL4 inactivates LPL by ...

Keywords:

Angiopoietin-like Protein
Cell biology
Lipoprotein lipase
Membrane protein
ANGPTL4
GPIHBP1
Unfolded protein response
Hydrolase
Biochemistry
Biology
Familial Chylomicronemia
Protein domain
Angiopoietin-like 4 Protein
Protein folding

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