Breast cancer in young women of Chinese Han population: A retrospective study of patients under 25 years.

Abstract Background Breast cancer has aggressive clinical and pathological features in younger women and is characterized by poorer prognosis than in older women. However, data on women Objective The aim of the present study was to evaluate the different pathological characteristics and prognostic factors in Chinese women with breast cancer Methods This retrospective study included 94 patients (aged Results The HER2-positive and triple-negative groups had a higher T (P = 0.002) and N stage than the luminal A group (P = 0.014). The 5-year overall survival (OS) was 90.4%, and the disease-free survival (DFS) was 74.5%. The 5-year DFS varied among the four groups were 94.1 vs. 76.9 vs. 45.5 vs. 66.7%, respectively; P = 0.009. Multivariate analysis showed that only estrogen receptor (ER) status was a significant predictor of OS and DFS [Hazard ratio (HR) = 5.3, 95% confidence interval (CI) = 1.11-25.27, P = 0.036; HR = 2.712, 95%CI = 1.27-5.80, P = 0.01). Conclusion HER2-positive and triple-negative breast cancer are more likely to have poor prognosis in patients