Histophysiological changes in vas deferens after vasectomy and the prophylactic action of ascorbic acid in mature male albino rats (Rattus norvegicus Berkenhaut; Rodentia)

SUMMARY Vasectomy (30, 60, 90 days) in mature male albino rats (Rattus norvegiens Berkenhaut; Rodentia) altered sperm morphology, density, and motility, as well as androgenic metabolism and the histology of both the proximal and distal vas deferens accompanied by changes in the metal ion profile. A sperm granuloma was seen in the proximal vas deferens. The ascorbate turnover was significantly altered. It is suggested that the above changes might affect the internal milieu of vas deferens. Ascorbate feeding on the other hand, brought about recovery in the histophysiology of vas deferens and thereby manifested a beneficial effect. The use of ascorbic acid in the prophylaxis of vasectomized men is suggested.