BiCl3-Catalyzed Propargylic Substitution Reaction of Propargylic Alcohols with C-, O-, S- and N-Centered Nucleophiles.

A general and efficient BiCl3-catalyzed substitution reaction of propargylic alcohols with carbon and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols and amides, leading to the construction of C–C, C–O, C–S and C–N bonds, has been developed.