Laser pulse shaping to increase brain blood flow sensitivity of time-domain diffuse correlation spectroscopy

Stefan A. Carp,Adriano Peruch,Davide Tamborini,Dibbyan Mazumder,Melissa M. Wu,Suk-Tak Chan,Mitchell B. Robinson,Jason Z. Qu,Guillaume Delpont,Thomas Schoenau,Alain Bourdon,Maria Angela Franceschini

Laser pulse shaping to increase brain blood flow sensitivity of time-domain diffuse correlation spectroscopy

2020

Stefan A. Carp
Adriano Peruch
Davide Tamborini
Dibbyan Mazumder
Melissa M. Wu
Suk-Tak Chan
Mitchell B. Robinson
Jason Z. Qu
Guillaume Delpont
Thomas Schoenau
Alain Bourdon
Maria Angela Franceschini

Time-domain diffuse correlation spectroscopy (TD-DCS) aims to increase cerebral blood flow (CBF) sensitivity by discriminating photon time of flight. We report on the optimization of the laser pulse shape to maximize TD-DCS performance.

Keywords:

Pulse shaping
Pulse (signal processing)
Cerebral blood flow
Laser
Spectroscopy
Optics
Avalanche photodiode
Time of flight
Time domain
Materials science

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