A digital technique for stimulus artifact reduction

Abstract A method of recovering compound muscle action potentials which are overwhelmed by a stimulus artifact is presented. In the specific example reported, such action potentials were recorded from the hamster diaphragm using an apposing platinum electrode for both stimulation and recording. To recover the artifact-free action potential, a combination of digital data acquisition and simple signal processing was employed. The recording of a stimulus artifact from a sub-threshold stimulus was used to subtract the artifact component from subsequent recordings and thus faithfully reveal the action potentials. The technique should find application in other preparations.