Expression of TLR1, TLR3 and TL7 genes remarkably down-regulated from erosion to peptic ulcer and gastric cancer development

Abstract Background Toll-like receptors (TLRs) play a pivotal role in pathogen recognition and induction of inflammation that lead to development of gastrointestinal disorders. Our study aimed to evaluate expression pattern of TLR1, 3, 4, 7, and 9 genes in erosion, peptic ulcer disease (PUD) and gastric cancer (GC). Methods Total RNA was extracted from gastric biopsy specimens and, then expression of TLRs genes was assessed through real time PCR. Results The obtained results indicated that TLR1 significantly decreased in GC when comparing to other groups. In addition, TLR1 was significantly increased in erosion group compared to control and GC groups. However, TLR1 expression in PUD, control and erosion groups did not show any significant difference. Through disease progression from gastric erosion to PUD and GC, TLR3 expression followed a significant descending expression pattern (p  Conclusions In summary, the obtained results confirmed that with gastrointestinal diseases development from erosion to PUD and GC, expression of TLRs especially TLR1, TLR3 and TL7 remarkably down-regulated.