anti-C5 antibodies that have improved pharmacokinetics

An isolated antibody or antigen binding fragment thereof that: (a) binds to the C5 component of human complement; (B) inhibits the cleavage of C5 into C5a and C5b fragments; and (c) comprises: (i) a heavy chain CDR1 comprising the amino acid sequence shown in SEQ ID NO: 23, (ii) a heavy chain CDR2 comprising the amino acid sequence shown in SEQ ID NO: 19, (iii) a heavy chain CDR3 comprising the amino acid sequence shown in SEQ ID NO: 3, (iv) a light chain CDR1 comprising the amino acid sequence shown in SEQ ID NO: 4, (v) a CDR2 light chain comprising the amino acid sequence shown in SEQ ID NO: 5, and (vi) a light chain CDR3 comprising the amino acid sequence shown in SEQ ID NO: 6.