Certain bioactive effects of complexes rich in glycosaminoglycans obtained from small sea fish

The extracts rich in glycosaminoglycans (GAGs) were obtained through a proper-patented technology from small sea fish (Sprattus sprattus sprattus, Odontogadus merlangus euxinus and Engraulis encrassicolus ponticus species). These natural bioactive complexes demonstrate a significant inhibition action against hyaluronidase, collagenase and elastase, the enzymes implicated in the pathology of conjunctive, cartilaginous and bone tissues and favor the in vitro formation of collagen fibrils, these biochemical processes being dependent of the bioactive compound system concentration. Also, their high content in sulfated glycosaminoglycans (44%), essential amino acids, essential fatty acids and microelements such as Ca, Na, K, Fe, Mg, Se, Ni, Cu, Si, make the bioactive extracts from small see fish useful to prevent the unsettle of the macromolecular structure and keep the functionality of the extracellular matrix from conjunctive, cartilaginous and bone tissue.