Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Brandt Huddle,Edward Grimley,Cameron D. Buchman,Mikhail Chtcherbinine,Bikash Debnath,Pooja Mehta,Kun Yang,Cynthia A. Morgan,Siwei Li,Jeremy Felton,Duxin Sun,Geeta Mehta,Nouri Neamati,Ronald J. Buckanovich,Thomas D. Hurley,Scott D. Larsen

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

2018

Brandt Huddle
Edward Grimley
Cameron D. Buchman
Mikhail Chtcherbinine
Bikash Debnath
Pooja Mehta
Kun Yang
Cynthia A. Morgan
Siwei Li
Jeremy Felton
Duxin Sun
Geeta Mehta
Nouri Neamati
Ronald J. Buckanovich
Thomas D. Hurley
Scott D. Larsen

Aldehyde dehydrogenase (ALDH) activity is commonly used as a marker to identify cancer stem-like cells. The three ALDH1A isoforms have all been individually implicated in cancer stem-like cells and...

Keywords:

Aldehyde dehydrogenase
Ovarian cancer
Cancer research
Chemistry
Subfamily
Chemotherapy
structure based

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