Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques

Philip J. Santangelo,Kenneth A. Rogers,Chiara Zurla,Emeline L. Blanchard,Sanjeev Gumber,Karen Strait,Fawn Connor-Stroud,David M. Schuster,Praveen K. Amancha,Jung Joo Hong,Siddappa N. Byrareddy,James A. Hoxie,Brani Vidakovic,Aftab A. Ansari,Eric Hunter,Francois Villinger

Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques

2015

Philip J. Santangelo
Kenneth A. Rogers
Chiara Zurla
Emeline L. Blanchard
Sanjeev Gumber
Karen Strait
Fawn Connor-Stroud
David M. Schuster
Praveen K. Amancha
Jung Joo Hong
Siddappa N. Byrareddy
James A. Hoxie
Brani Vidakovic
Aftab A. Ansari
Eric Hunter
Francois Villinger

ImmunoPET/CT imaging using a labeled SIV-specific antibody can identify sites of viralinfection in SIV-infected macaques without the need for tissue biopsies, even if viral load in the blood is below the detection limit.

Keywords:

Viral replication
Antibody
Whole body imaging
Emtricitabine
Virology
Immunology
Simian immunodeficiency virus
Viral load
Immunohistochemistry
Viremia
Biology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

109

Citations