Functional MRI and Applications in Dermatology

Abstract As a non-invasive imaging modality able to demonstrate dynamic changes in neurologic activity, functional magnetic resonance imaging (fMRI) has revolutionized the ability to both map and further understand functional regions of the brain. Current applications range from neurosurgical planning to an enormous variety of investigational applications across many diverse specialties. The main purpose of this article is to provide a foundational understanding of how fMRI is being used in research by outlining the underlying basic science, specific methods, and direct investigational and clinical applications. In addition, the use of fMRI in current dermatologic research, especially in relation to studies concerning the skin-brain axis, is explicitly addressed. This article also touches on the advantages and limitations concerning fMRI in comparison to other similar techniques.