Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Eisuke Ota,Masatoshi Takeiri,Miyuki Tachibana,Yuichi Ishikawa,Kazuo Umezawa,Shigeru Nishiyama

Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

2012

Eisuke Ota
Masatoshi Takeiri
Miyuki Tachibana
Yuichi Ishikawa
Kazuo Umezawa
Shigeru Nishiyama

Abstract Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.

Keywords:

Streptomyces
Glutarimide
DTCM-glutarimide
Molecular probe
9-methylstreptimidone
Biochemistry
Stereochemistry
Chemistry
no production
biological evaluation

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