Cytotoxic, Anti-bacterial, and Wound-healing Activity of Prenylated Phenols from the Kurdish Traditional Medicinal Plant Onobrychis Carduchorum (Fabaceae)
2020
Onobrychis carduchorum (Fabaceae) is a plant widely employed in Kurdish
traditional medicine to cure wounds, inflammations, and other skin diseases. We
could isolate ten different polyphenols from the acetone extract of this plant:
1–4 are isoflavones, having a genistein skeleton;
5–7 are flavanones, having a naringenin skeleton; and
8–10 are prenylated dihydro-stilbenes. In particular,
8–10 have been isolated, so far, only from
Glycyrrhiza glabra (liquorice). Many of the above prenylated phenols
showed significant toxicity on some human breast cancer cell lines, and a
relevant growth inhibition of Staphylococcus aureus strains. In addition,
9 and 10 had marked wound healing activity. It is suggested
that these bioactivities are responsible, at least partly, for the
plant’s traditional use.
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