Molecular design of alkylating pyrrole-imidazole polyamides with indole linker
2004
A series of novel DNA alkylating polyamide possessing indole linker was synthesized. The reactivities and specificities of these polyamides with double strand DNA were investigated by using high-resolution gel electrophoresis. The results revealed that the indole linker linked Py-Im polyamides have the high alkylating activities and sequence specificities comparable to vinyl linker linked Py-Im polyamides.
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