heterociciclos condensed compounds as inhibitors of tyrosine kinases pproteina.

THE SUBSTITUTE heteroaromatic compounds of formula (I) AND IN PARTICULAR quinolines and substituted quinazolines are inhibitors of protein tyrosine kinase-. COMPOUNDS well as procedures for their preparation, pharmaceutical compositions containing such compounds and their use in medicine, for example IN THE TREATMENT OF CANCER AND PSORIASIS, or a salt or solvate thereof are described. In the formula, X is not CH; Y is a group W (CH 2) (CH 2) WOW, BEING WO, S (O) m m is 0, 1 or 2, O THAT NR A R 1 is hydrogen or an alkyl group C 1- 8; R 1 represents a phenyl group or a heterocyclic 5- or 6-membered containing 1 to 4 heteroatoms selected from N, OOS (O) M in which M is as defined above, provided that the ring does not contain two ATOMOS OOS (O) M ADJACENT AND WHEN THE RING ONLY CONTAIN N as the hetero atom (S) THE RING IS LINK THROUGH A carbon atom to the quinazoline ring or quinoline, SIENDOR 1 optionally substituted by one or more groups R 3; P = 0 to 3; YU, R 2, R 3 REPRESENT DEFINED IN THE APPLICATION.