A TREK Channel Family Activator with Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation

Yunguang Qiu,Lu Huang,Jie Fu,Chenxia Han,Jing Fang,Ping Liao,Zhuo Chen,Yiqing Mo,Peihua Sun,Daqing Liao,Linghui Yang,Jing Wang,Qiansen Zhang,Jin Liu,Feng Liu,Tingting Liu,Wei Huang,Huaiyu Yang,Ruotian Jiang

A TREK Channel Family Activator with Well-Defined Structure-Activation Relationship for Pain and Neurogenic Inflammation

2020

Yunguang Qiu
Lu Huang
Jie Fu
Chenxia Han
Jing Fang
Ping Liao
Zhuo Chen
Yiqing Mo
Peihua Sun
Daqing Liao
Linghui Yang
Jing Wang
Qiansen Zhang
Jin Liu
Feng Liu
Tingting Liu
Wei Huang
Huaiyu Yang
Ruotian Jiang

TWIK-related K+ (TREK) channels are potential analgesic targets. However, selective activators for TREK with both defined action mechanism and analgesic ability for chronic pain have been lacking. ...

Keywords:

Neurogenic inflammation
Chronic pain
Activator (genetics)
Pharmacology
Analgesic
Biochemistry
Chemistry

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