Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory pain

Abstract A series of 3-amino-6-aryl-pyridazines have been identified as CB 2 agonists with high efficacy and selectivity against the CB 1 receptor. Details of the investigation of structure–activity relationships (SAR) are disclosed, which led to the identification of pyridazine analogue 35 , a compound with high potency in an in vivo model of inflammatory pain.