Simple and effective method for producing [11C]phosgene using an environmental CCl4 gas detection tube

Abstract Introduction Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [ 11 C]phosgene, some difficulties, especially in the formation of [ 11 C]phosgene process from [ 11 C]CCl 4 , hamper its use. The present article shows a simple preparation method for [ 11 C]phosgene. Method [ 11 C]CCl 4 was obtained using the conventional method by passing a mixture of [ 11 C]CH 4 and Cl 2 through a heated quartz tube. The [ 11 C]CCl 4 was transformed to [ 11 C]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl 4 concentration measurement at room temperature with a flow rate of 50 ml/min. Result This tube successfully transformed [ 11 C]CCl 4 to [ 11 C]phosgene at room temperature. [ 11 C]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility. Conclusion A high yield and reliable [ 11 C]phosgene production method using a gas detector tube system for working-environmental CCl 4 concentration measurement was developed.