Novel imidazole derivatives with subtype-selective antimuscarinic activity (1)
1998
A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1− and M3-selective antimuscarinic agent.
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