First application of the Dakin-West reaction to fmoc chemistry: Synthesis of the ketomethylene tripeptide fmoc-Nα-Asp(tBu)-(R,S Tyr(tBu)Ψ(CO-CH2)Gly-OH
1995
Abstract A practical synthesis of a tripeptide containing a ketomethylene isostere, suitably protected for introduction in Fmos SPPS, has been carried out for the first time in Fmoc chemistry by using a modified Dakin-West reaction.
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