Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection

Thibaut Brugat,Adam J. Reid,Jing-wen Lin,Deirdre Cunningham,Irene Tumwine,Garikai Kushinga,Sarah McLaughlin,Philip J Spence,Ulrike Böhme,Mandy Sanders,Solomon Conteh,Ellen Bushell,Tom Metcalf,Oliver Billker,Patrick E. Duffy,Chris I. Newbold,Matthew Berriman,Jean Langhorne

Antibody-independent mechanisms regulate the establishment of chronic Plasmodium infection

2017

Thibaut Brugat
Adam J. Reid
Jing-wen Lin
Deirdre Cunningham
Irene Tumwine
Garikai Kushinga
Sarah McLaughlin
Philip J Spence
Ulrike Böhme
Mandy Sanders
Solomon Conteh
Ellen Bushell
Tom Metcalf
Oliver Billker
Patrick E. Duffy
Chris I. Newbold
Matthew Berriman
Jean Langhorne

In rodent models, only a minority of infecting Plasmodium parasites, expressing one of several clusters of virulence-associated pir genes, establishes a chronic infection in a manner that is independent of adaptive immunity.

Keywords:

Antibody
Acquired immune system
Gene
Virology
Immunology
Biology
Plasmodium falciparum
Population
chronic infection
Plasmodium knowlesi
Malaria
Antigen

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