A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

Bingqi Tong,Jessica N. Spradlin,Luiz F. T. Novaes,Erika Zhang,Xirui Hu,Malte Moeller,Scott M. Brittain,Lynn M. McGregor,Jeffrey M. McKenna,John A. Tallarico,Markus Schirle,Thomas J. Maimone,Daniel K. Nomura

A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL

2020

Bingqi Tong
Jessica N. Spradlin
Luiz F. T. Novaes
Erika Zhang
Xirui Hu
Malte Moeller
Scott M. Brittain
Lynn M. McGregor
Jeffrey M. McKenna
John A. Tallarico
Markus Schirle
Thomas J. Maimone
Daniel K. Nomura

Targeted protein degradation (TPD) and proteolysis-targeting chimeras (PROTACs) have arisen as powerful therapeutic modalities for degrading specific proteins in a proteasome-dependent manner. Howe...

Keywords:

protein degradation
Biochemistry
Chimera (genetics)
Cell biology
Kinase
therapeutic modalities
Biology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations