Wound Infection and Biofilms

The existence of biofilms in wounds is now clearly evident, with their role being significant in inhibiting the healing process. All chronic wounds are colonised by bacteria encased within a polymicrobial biofilm contributing to a prolonged inflammatory response in the host. Proteases released by sessile bacteria, possibly in synergy with human proteases, may destroy human growth factors and other tissue proteins thought to be essential to the wound-healing process. Subsequently a better understanding of the physiology of biofilms in wounds may aid in the development of more effective methods of treatment and, ultimately, better prognoses for patients.