Mechanisms of splicing-dependent trans -synaptic adhesion by PTPδ–IL1RAPL1/IL-1RAcP for synaptic differentiation

Synapse formation depends on trans-synaptic interactions between selective pairs of pre- and postsynaptic adhesion molecules. Here, the authors establish the basis for the splice isoform-dependent selectivity of receptor protein tyrosine phosphatase δ as it forms trans-synaptic contacts with IL1RAPL1 and IL-1RAcP.