Synthesis of Two Tumor-Associated Oligosaccharides: Di- and Trifucosylated Para-Lacto-N-Hexaose
1991
ABSTRACT Di- and trifucosylated derivatives (21 and 22) of para-lacto-N-hexaose were synthesized. Both structures have been shown to be present in small quantities in human milk, and have also been indicated as tumor-associated antigens. Thioglycoside mono- and disaccharide blocks were used to assemble a properly protected linear hexaose. Di- and trifucosylation at appropriate positions followed by deprotection then gave the desired oligosaccharides.
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