The target cell plasma membrane and steroid hormones: the beginning or end of the debate?

Drawing on experience gained in previous studies, the authors propose their own approach to defining the role the plasma membrane of the target cell plays in the mechanism of action of steroid hormones. The properties of membrane receptors for glucocorticoids on lymphoid cells are identified and examined, and possible ways in which the hormonal signal is transformed into a biological response of the target cell are described. The results provide a theoretical basis for the development of novel diagnostic techniques and pharmaceutical preparations.