Preparation of Rare L-idose Derivatives from D-glucofuranose via Neighboring Acyl Group Assistance
2021
Abstract An efficient protocol for preparation of rare L-idose derivatives from 5-OH D-glucofuranose derivatives was developed, and the stereo-inversion of 5-OH was assisted by neighboring acyl group. A library of L-idose derivatives with various protective groups at C3 and C6 positions were obtained from the corresponding D-glucofuranose derivatives in good to high yields, which provides an alternative approach for the synthesis of L-iduronic acid building blocks when assembling heparin-like oligosaccharides. And the mechanism of the stereo-inversion reaction was proposed.
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