Synthesis of 3β-Amino-5α-Androstan-17-One from Epiandrosterone

3-Aminosteroids have been obtained starting from 3-hydroxysteroids by tosylation azide formation and reduction to an amine. This method leads to inversion of configuration at position 3. In this work we have developed an alternative way for the synthesis to 3β-amino-5α-androstan-17-one in four steps without inversion of the substituent configuration and with a good yield.