Synthesis and the Stimuli-Responsive Characteristics of Cyclic Cholamide Nicotinamide Adenine Dinucleotide (NAD+) Derivative with Aggregation in Basic Aqueous Solution

A cyclic cholamide nicotinamide adenine dinucleotide (NAD+) derivative (CCN) has been synthesized with high yield. CCN is able to form nanomicelles in basic aqueous solution and emits fluorescence. The emission intensity shows a good linear relation and a good reversibility with pH value (pH 7–11). The mechanism for pH-mediated changes in optical properties was demonstrated to be the tautomeric equilibriums of CCN/CCN-OH.