The Biomimetic Total Syntheses of the Antiplasmodial Tomentosones A and B.

The first biomimetic total syntheses of natural phloroglucinols tomentosones A and B and their analogues have been accomplished. The synthetic strategy primarily referred to the potential biosynthetic precursors and their possible sequence of segments assembly by chemological evolution of the structural entities and enabled rapid access of the titled compounds in a practical fashion.