Cross-Coupling Reactions of Aryl Halides with Amines, Phenols, and Thiols Catalyzed by an N,N′-Dioxide–Copper(I) Catalytic System

The coupling reactions of various N, O, and S nucleophilic reagents with aryl halides have been successfully carried out under mild conditions by using a novel chiral N,N′-dioxide–copper(I) catalytic system as the catalyst. This versatile and efficient catalyst system has been demonstrated to facilitate the cross-coupling reactions of aryl halides with amines,phenols, and thiols to afford the corresponding desired products in good to excellent yields.