Loss of DNA methylation is related to increased expression of miR-21 and miR-146b in papillary thyroid carcinoma

Isabella Maria Dias Payão Ortiz,Mateus Camargo Barros-Filho,Mariana Bisarro dos Reis,Caroline Moraes Beltrami,Fabio Marchi,Hellen Kuasne,Luisa M Canto,Julia Bette Homem de Mello,Cecilie Abildgaard,Clóvis Antônio Lopes Pinto,Luiz Paulo Kowalski,Silvia Regina Rogatto

Loss of DNA methylation is related to increased expression of miR-21 and miR-146b in papillary thyroid carcinoma

2018

Isabella Maria Dias Payão Ortiz
Mateus Camargo Barros-Filho
Mariana Bisarro dos Reis
Caroline Moraes Beltrami
Fabio Marchi
Hellen Kuasne
Luisa M Canto
Julia Bette Homem de Mello
Cecilie Abildgaard
Clóvis Antônio Lopes Pinto
Luiz Paulo Kowalski
Silvia Regina Rogatto

Background DNA methylation in miRNA genes has been reported as a mechanism that may cause dysregulation of mature miRNAs and consequently impact the gene expression. This mechanism is largely unstudied in papillary thyroid carcinomas (PTC).

Keywords:

Carcinoma
Gene expression
Cancer research
DNA methylation
Thyroid
Gene
microRNA
Human genetics
Biology
Thyroid Carcinomas
Transfection
Transcription (biology)
Biological pathway
Methylation

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