Dual Electrophilic Trapping-NegishiCoupling with Dilithiothiophenes in a Three-Component, One-Pot Process

Based upon a twofold bromine―lithium exchange with 2,5-dibromo thiophene and sequential trapping of the dilithio intermediate, organo zinc halides were generated in situ and subsequently transformed by Negishi cross-coupling to unsymmetrically substituted thiophenes in a one-pot fashion. Application of this novel sequence to diiodo(hetero)arenes quickly furnishes highly interesting building blocks for materials science applications.