Formulation Characteristics of Three Kinds of Elravie(R) Fillers

Background: Hyaluronic acid (HA) is a mucopolysaccharide that occurs naturally throughout the human body, where it attaches to collagen and elastin to form cartilage, and also helps maintain the strength and flexibility of the cartilage that cushions joints. A decline in HA synthesis may lead to a variety of symptoms, ranging from joint discomfort, to wrinkles. Cross-linked HA is a viscoelastic solid that resists in vivo degradation by hyaluronidase for much longer than endogenous HA, and which is also a key ingredient in various cosmetics. Objective: To describe our experience with three kinds of ElravieR fillers. Methods: We obtained images of filler shape using a folliscope. Scanning electron microscopy (SEM) was used to compare particle sizes. Hydrophilic filler is a hydroxyl, and for this reason, we mixed the filler with water. Next, PARKER ink was added to the mixture, and viscosity and elasticity were measured using a rheometer. Results: Among the tested fillers, particle size was largest in the RestylaneR SubQ. ElravieR ultra volume filler was greater in volume than Elravie R deep line, and Elravie R light fillers. We confirmed Elravie R fillers to be hydrophilic. ElravieR ultra volume filler was found to have the highest viscosity and elasticity, whilst ElravieR light filler had the lowest. Conclusion: All three kinds of Elravie R fillers were found to be suitable for human cosmetic use. (Korean J Dermatol 2014;52(2):100∼105)