Escalated cocaine “binges” in rats: enduring effects of social defeat stress or intra-VTA CRF
2017
Rationale
Exposure to intermittent social defeat stress elicits corticotropin releasing factor (CRF) release into the VTA and induces long-term modulation of mesocorticolimbic dopamine activity in rats. These adaptations are associated with an intense cocaine-taking phenotype, which is prevented by CRF receptor antagonists.
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