DNA content in atypical glio-mesenchymal cells during chemical carcinogenesis in the albino rat cerebellum

The DNA content was determined by comparative microspectrophotometry in atypical glio-mesenchymal cells around the villous capsule surrounding the DMBA pellet, and in cells of microastrocytomas and microglioblastomas induced by DMBA. A characteristic feature of the late stages of this type of chemical carcinogenesis in the albino rat cerebellum was found to be the preservation of a well-marked diploid modal class, except in cases when the pathological process developed along malignant lines in the early stages of tumor progression (microglioblastoma).