Identification of potentially useful combinations of epidermal growth factor receptor tyrosine kinase antagonists with conventional cytotoxic agents using median effect analysis.

Daniel R. Budman,Richie Soong,Anthony Calabro,Julia Tai,Robert B. Diasio

Identification of potentially useful combinations of epidermal growth factor receptor tyrosine kinase antagonists with conventional cytotoxic agents using median effect analysis.

2006

Daniel R. Budman
Richie Soong
Anthony Calabro
Julia Tai
Robert B. Diasio

Targeted therapy for breast carcinoma has achieved a major advance with the use of trastuzumab in Her2/neu-positive tumors. The epidermal growth factor receptor superfamily thus becomes an attractive target for therapeutic agents. As the epidermal growth factor receptor tyrosine kinase family has a

Keywords:

Tropomyosin receptor kinase C
Receptor tyrosine kinase
Insulin-like growth factor 1 receptor
Epidermal growth factor receptor
Biochemistry
Growth factor receptor inhibitor
Tyrosine kinase
Growth factor receptor
Platelet-derived growth factor receptor
Biology

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