A Matrix Factorization Classifier for Knowledge-Based Microarray Analysis

In this study we analyze microarray data sets which monitor the gene expression levels of human peripheral blood cells during differentiation from monocytes to macrophages. We show that matrix decomposition techniques are able to identify relevant signatures in the deduced matrices and extract marker genes from these gene expression profiles. With these marker genes corresponding test data sets can then easily be classified into related diagnostic categories. The latter correspond to either monocytes vs macrophages or healthy vs Niemann Pick C diseased patients. Our results demonstrate that these methods are able to identify suitable marker genes which can be used to classify the type of cell lines investigated.