Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase1 (IDO1) Inhibitors

Qinglin Pu,Hongjun Zhang,Liangqin Guo,Mangeng Cheng,Amy C. Doty,Heidi Ferguson,Xavier Fradera,Charles A. Lesburg,Meredeth A. McGowan,J. Richard Miller,Prasanthi Geda,Xuelei Song,Karin M. Otte,Nunzio Sciammetta,Nicolas Solban,Wensheng Yu,David L. Sloman,Hua Zhou,Alfred Lammens,Lars Neumann,David Jonathan Bennett,Alexander Pasternak,Yongxin Han

Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase1 (IDO1) Inhibitors

2020

Indoleamine-2,3-dioxygenase 1 (IDO1) inhibition and its combination with immune checkpoint inhibitors like pembrolizumab have drawn considerable attention from both academia and the pharmaceutical ...

Keywords:

Cancer immunotherapy
Potency
Pentane
Bicyclic molecule
Pembrolizumab
Pharmacology
Biology
immune checkpoint inhibitors
Pharmacokinetics

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations