Effects of 99m Tc on the Redox Properties of L-Thyroxine

This paper presents the redox properties of hypothyroid drug L-thyroxine without and in the presence of sodium pertechnetate (99mTc) by an electrochemical method on glassy-carbon (GC) electrodes using a cyclic voltammetry technique. The cyclic voltammetry method was used to investigate the effects of various concentrations of L-thyroxine without and in the presence of 99mTc radiopharmaceuticals, the effect of the number of scan cycles, as well as the effect of 99mTc activity on the appearance of cyclic voltammograms. The results show that with the increase of the concentration of L-thyroxine, the increase of the peak current in the reduction area is notable. Obtained results show that the application of different concentrations of 99mTc on the drug exhibits the inhibitory properties of used radiopharmaceutical in the treatment of hypothyroidism.