Imidazole moiety replacements in the 3 -(1H -benzo[d]imidazol-2 -yl )pyridin -2 (1H) -one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

Abstract A series of 3-(1 H -benzo[d]imidazol-2-yl)pyridin-2(1 H )-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) were examined in which the pendant imidazole moiety was replaced to improve selectivity for IGF-1R inhibition over cytochrome P450 (CYP). Synthesis and SAR of these compounds is presented.